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目的：对肾动态显像法测定肾小球滤过率(glomerular filtration rate，GFR)与双血浆法进行比较，以评价肾动态显像法测定肾小球滤过率的可靠性。方法：原发或继发慢性肾脏病患者54例，按常规方法进行肾动态显像，采用仪器中的处理程序(Gates 法)进行图像处理得到 GFR；静脉注射锝-99m-二乙三胺五乙酸(~(99)Tc~m-DTPA)后2h 及4h 取血，测定1mL 血浆中的放射性计数，用双血浆法计算公式求得 GFR，对肾动态显像法与双血浆法测的GFR 进行相关性分析，并比较两者测得的 GFR 与血清尿素(urea)及肌酐(creatinine，Cr)水平的关系。结果：肾动态显像法与双血浆法测得的 GFR 值具有良好的相关性(r=0.881 5，P＜0.01)，两者的直线回归方程为，GFR(肾动态显像法)=0.661 4 GFR(双血浆法)+21.89；肾动态显像法与双血浆法测得的 GFR 与 urea 及 Cr 的相关性直线相近，表明二者几乎以相同的数量关系反映肾功能的变化；2例偏瘦的病人和1例偏胖的病人两种方法测得的GFR 差异较大。结论：一般情况下肾动态显像法测得的 GFR 能够可靠地反映肾功能的变化，与双血浆法测得的GFR 相符合，但对于特殊体形的患者，肾动态显像法测得的 GFR 可能会有较大的偏差。
OBJECTIVE: To compare glomerular filtration rate (GFR) with double plasma in renal dynamic imaging to evaluate the reliability of renal dynamic imaging in determining glomerular filtration rate. Methods: Fifty-four patients with primary or secondary chronic kidney disease underwent renal dynamic imaging according to the routine method. The Gates method was used for image processing to obtain GFR. Intravenous injection of technetium-99m-diethylenetriaminepentaamine Blood samples were collected at 2h and 4h after acetic acid (~ (99) Tc ~ m-DTPA) to determine the radioactivity of 1mL plasma. The GFR was calculated by the double plasma method. The GFR The correlation between GFR and serum urea and creatinine (Cr) levels was compared. Results: There was a good correlation between GFR and renal dynamic imaging (r = 0.881 5, P <0.01). The linear regression equation was GFR (renal dynamic imaging) = 0.661 4 GFR (double plasma method) +21.89; renal dynamic imaging and double plasma measured GFR and urea and Cr linear correlation similar, indicating that the two almost the same quantitative relationship between changes in renal function; 2 cases The GFR measured by the two methods of a lean patient and a patient who is overweight is quite different. CONCLUSIONS: In general, GFR measured by renal dynamic imaging can reliably reflect the change of renal function, which is consistent with the GFR measured by double plasma method. However, for patients with special body shape, GFR measured by dynamic renal imaging There may be a big deviation.