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目的探讨检测血清高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)和白细胞介素-6(interleukin-6,IL-6)对冠心病患者的临床意义。方法检测83例接受经皮冠状动脉介入术治疗的冠心病患者介入治疗前及治疗3个月后血清hs-CRP及IL-6水平,其中急性心肌梗死组16例,不稳定心绞痛组38例,稳定性心绞痛组29例,并与41例健康体检者(对照组)进行比较。结果治疗前急性心肌梗死组和不稳定心绞痛组血清hs-CRP和IL-6水平明显高于对照组(P<0.01);稳定性心绞痛组血清hs-CRP水平高于对照组(P<0.01);治疗3个月后冠心病3组血清hs-CRP和IL-6水平明显下降,与对照组比较差异无统计学意义(P>0.05)。结论血清hs-CRP和IL-6水平对冠心病患者治疗及预后有一定价值。
Objective To investigate the clinical significance of detecting serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with coronary heart disease. Methods Serum levels of hs-CRP and IL-6 were measured in 83 patients with coronary heart disease undergoing percutaneous coronary intervention before intervention and 3 months after treatment. Among them, 16 were acute myocardial infarction, 38 were unstable angina, Forty-nine patients with stable angina were compared with 41 healthy controls (control group). Results The levels of hs-CRP and IL-6 in acute myocardial infarction group and unstable angina group before treatment were significantly higher than those in control group (P <0.01). The serum hs-CRP level in stable angina pectoris group was higher than that in control group (P <0.01) ; After 3 months of treatment, the levels of serum hs-CRP and IL-6 in the three groups of coronary heart disease significantly decreased compared with the control group (P> 0.05). Conclusion The serum levels of hs-CRP and IL-6 have some value in the treatment and prognosis of patients with coronary heart disease.