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某些研究者提出二硫化碳(CS_2)中毒的神经毒作用,是与中枢神经系统能量代谢失调有关。然并无充分材料证明,且常是以间接指征为依据。本文作者总结了其一些研究结果,旨在证明目前的假设和观点。该研究是用大鼠做急性和慢性CS_2接触试验,不论在急性或慢性CS_2中毒后,其结果和某些作者的意见相反,均未发现糖酵解的变化,脑中葡萄糖与乳酸盐的浓度无改变,甚至也未观察到~(14)C-葡萄糖代谢率的变化。另一方面,在参与三羧酸循环代谢的游离氨基酸的代谢中发现有很大的变化。将大鼠连续15小时急性接触CS_2(2.5 mg/l)后,其脑中谷氨酸与γ-氨基丁酸的浓度较低,而谷酰胺的浓度则很高。通过利用~(14)C-葡萄糖与~(14)C-丁酸盐,发现游离氨基酸的代谢紊乱,它仅与谷氨酸的一个代谢间隔(compartment)有关,这所谓的谷氨酸的“小代谢库”,是丁酸盐(而
Some researchers have suggested that the neurotoxic effect of carbon disulfide (CS_2) poisoning is related to central nervous system energy metabolism disorders. However, there is no sufficient material to prove, and often based on indirect indications. The author summarizes some of its findings to prove the current assumptions and perspectives. In this study, rats were used for acute and chronic CS2 exposure tests. No evidence of changes in glycolysis was found after acute or chronic CS2 poisoning, contrary to the opinions of some authors. Glucose and lactate There was no change in concentration and no changes in ~ (14) C-glucose metabolism were observed. On the other hand, great changes have been found in the metabolism of free amino acids involved in the metabolism of tricarboxylic acids. After acute exposure to CS_2 (2.5 mg / l) for 15 hours, the glutamate and γ-aminobutyric acid concentrations in the brain were lower, while the glutamine concentrations were higher in the brain. By using ~ (14) C-glucose and ~ (14) C-butyrate, it was found that the metabolic disorder of free amino acids was related only to one compartment of glutamate, the so-called glutamate “ Small Metabolites ”, is butyrate (and