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目的:观察奥沙利铂、亚叶酸钙和氟尿嘧啶方案联合金龙胶囊治疗晚期大肠癌的临床疗效和不良反应。方法:80例患者随机分为两组:单纯化疗组(对照组)40例,奥沙利铂130 mg·m-2第1天+CF 100 mg·m-2第1~5天+5-Fu 500 mg·m-2第1~5天,每3周为1个周期,2个周期后评价疗效;金龙胶囊+化疗组(治疗组)40例,在单纯化疗组基础上加服金龙胶囊(北京健生药业有限公司生产),4粒·次-1,3次·d-1,连续服用30 d为1个疗程,间隔7 d再进行第2疗程。结果:治疗组临床疗效及生活质量改善优于对照组(P<0.05),治疗组化疗副反应明显低于对照组(P<0.05)。结论:金龙胶囊联合化疗可提高晚期大肠癌患者临床疗效及生活质量,同时减轻化疗反应。
Objective: To observe the clinical efficacy and adverse reactions of oxaliplatin, leucovorin and fluorouracil combined with Jinlong Capsule in the treatment of advanced colorectal cancer. Methods: Eighty patients were randomly divided into two groups: 40 patients in the chemotherapy alone group, 130 mg · m-2 oxaliplatin on day 1 + 100 mg · m-2 CF on day 1 to 5 and 5- Fu 500 mg · m-2 1 to 5 days, every 3 weeks for a cycle, 2 cycles after the evaluation of efficacy; Jinlong capsule + chemotherapy group (treatment group) 40 cases, on the basis of chemotherapy alone plus serving Jinlong capsule (Beijing Health Pharmaceutical Co., Ltd. production), 4 tablets · times -1,3 times · d-1, taking 30 consecutive days for a course of treatment, interval 7d and then the second course of treatment. Results: The clinical efficacy and quality of life in the treatment group were better than those in the control group (P <0.05). The side effects in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion: Jinlong capsule combined with chemotherapy can improve the clinical efficacy and quality of life of patients with advanced colorectal cancer, and reduce the response to chemotherapy.