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目的分析北京市抗感染类药物的严重不良反应报告,为临床安全合理使用抗感染类药物提供参考。方法详细收集全国药品不良反应监测中心北京地区所有不良反应报告,按人群、药品、不良反应情况等方面进行统计、分析。结果 184例严重不良反应中,33例为新的严重不良反应,涉及喹诺酮类、头孢类、抗病毒类、抗真菌类、抗结核菌类药物。不良反应累及了人体各个器官,其中较常见的为全身症状、消化系统、血液系统、皮肤及其附件、泌尿生殖系统。结论使用抗感染药物应严格按药品使用说明书用药,加强用药过程监护,做好不良反应上报工作,促进临床合理用药。
Objective To analyze the reports of serious adverse reactions of anti-infectives in Beijing and provide references for the safe and rational use of anti-infectives in clinical practice. Methods The National Adverse Drug Reaction Monitoring Center collected detailed reports on all adverse reactions in Beijing, and conducted statistics and analysis according to the population, drugs and adverse reactions. Results Of the 184 serious adverse reactions, 33 were new serious adverse reactions involving quinolones, cephalosporins, antivirals, antifungal and anti-tuberculosis drugs. Adverse reactions involving the various organs of the human body, of which the more common systemic symptoms, digestive system, the blood system, skin and its annexes, genitourinary system. Conclusion The use of anti-infective drugs should be strictly according to drug instruction manual medication, strengthen the medication process monitoring, reporting of adverse reactions to do to promote clinical rational drug use.