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目的 探讨人膀胱移行上皮癌多发性、复发性的细胞克隆来源。 方法 采用p53基因突变的PCR SSCP分析及DNA测序检测 6例患者 1 4个表浅、低分级原发加多发或复发的膀胱移行上皮癌标本及p2 1 WAF1 /CIP1 蛋白的表达。 结果 在 1 4个膀胱移行上皮癌标本中均有p53基因的点突变 ,同一例患者所有标本的点突变分别在同一位点上 ;1 4个膀胱移行上皮癌标本中仅有 5个有p2 1 WAF1 /CIP1 蛋白的表达。 结论 多发或复发膀胱移行上皮癌都可能来源于同一细胞 ,即单克隆起源。p2 1 WAF1 /CIP1 蛋白的表达既有 p53基因依赖性也有p53基因非依赖性途径
Objective To investigate the origin of multiple and recurrent cell clones in human bladder transitional cell carcinoma. Methods PCR-SSCP analysis and DNA sequencing were used to detect the expression of p21 WAF1 / CIP1 protein in 14 cases of bladder transitional epithelial carcinoma with superficial or low-grade primary or multiple recurrences. Results All 14 specimens of bladder transitional epithelial carcinoma had point mutations of p53 gene. All the specimens of the same patient had point mutations at the same site. Only 5 of 14 specimens of bladder transitional epithelial carcinoma had p21 WAF1 / CIP1 protein expression. Conclusions Multiple or recurrent bladder transitional cell carcinoma may originate from the same cell, that is, the origin of monoclonal. The expression of p2 1 WAF1 / CIP1 protein has both p53 gene-dependent and p53 gene-independent pathways