给41例癌症患者每4小时给头孢哌酮2g、美洛西林5g,或各给药1g、3g,结果,10例发生低前凝血酶血症,3例出血。10例中有2例肌酸酐值上升。6例血清转氨酶轻度上升,其中1例引起低前凝血酶血症。高用量组5例中有3例Ⅶ因子活性异常,低用量组7例中均未出现。引起低前凝血酶血症的10例患者给维生素K 后,都很快得到了改善。 To 41 patients with cancer every 4 hours to cefoperazone 2g, mezlocillin 5g, or the administration of 1g, 3g, the results, 10 cases of low prothrombinmia, 3 cases of bleeding. Creatinine levels increased in 2 of 10 patients. Six cases of serum aminotransferase slightly increased, of which 1 case caused by low prothrombinmia. Three of the five patients in the high-dose group were abnormal in activity of factor VII, and none in the low-dose group. Ten patients with hypothyrexemia developed vitamin K very quickly.