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目的探讨药物超敏反应综合征(DIHS)引起暴发性T1DM(FT1DM)的临床特点、原因及致敏药物,为临床诊治提供参考。方法报道我院1例DIHS致使FT1DM病例,并通过检索1950~2016年发表在PubMed的相关文献进行分析。结果综合文献报道以及我院DIHS致FT1DM 22例,14例患者的人疱疹病毒6型(HHV-6)阳性,多见于卡马西平、美西律、别嘌醇药物激发引起,治疗上可使用糖皮质激素。结论DIHS可导致FT1DM的发生,出现DIHS时,注意监测血糖。
Objective To investigate the clinical features, causes and sensitizing drugs of drug-induced allergic reaction syndrome (DIHS) in patients with fulminant T1DM (FT1DM), so as to provide reference for clinical diagnosis and treatment. Methods A case of FT1DM caused by DIHS in our hospital was reported and analyzed by searching published articles published in PubMed between 1950 and 2016. Results In the literature and in our hospital, 22 cases of FT1DM caused by DIHS and 14 cases of human herpesvirus type 6 (HHV-6) positive were found in carbamazepine, mexiletine and allopurinol drugs and could be used therapeutically Glucocorticoids. Conclusion DIHS can lead to the occurrence of FT1DM. When DIHS occurs, pay attention to monitoring blood sugar.