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目的探讨子痫前期患者血浆不对称性二甲基精氨酸(asymmetric dimethylarginine,ADMA)水平与同型半胱氨酸(homocysteine,Hcy)水平的相关性,以及ADMA、Hcy水平与子痫前期的关系。方法将93例子痫前期患者分为轻、重度两个亚组,同期正常的健康孕妇50例作为对照组。采用酶联免疫吸附法检测血浆ADMA浓度,化学发光免疫法检测血清Hcy浓度,比较组间血浆ADMA及血清Hcy水平,分析血浆ADMA与血清Hcy水平的相关性。结果轻、重度子痫前期组血浆ADMA水平均高于对照组,差异均有统计学意义(P<0.05;P<0.01);轻、重度子痫前期组血清Hcy水平均高于对照组,差异有统计学意义(均P<0.05)。Pearson相关分析显示,血浆ADMA水平与Hcy水平呈正相关(r=0.813,P<0.000)。线性逐步回归分析发现,血浆ADMA水平随血清Hcy水平的升高而增加,呈线性趋势(β=9.453,P<0.01)。结论子痫前期患者血浆ADMA、血清Hcy水平均升高,这二者的升高可能与子痫前期的发生、发展有关,ADMA、Hcy可能都是子痫前期的危险因素。
Objective To investigate the relationship between asymmetric dimethylarginine (ADMA) levels and homocysteine (Hcy) levels in patients with preeclampsia and the relationship between ADMA and Hcy levels and preeclampsia . Methods Ninety-three patients with preeclampsia were divided into mild and severe subgroups, and 50 healthy pregnant women in the same period were taken as control group. Plasma ADMA concentration was detected by enzyme-linked immunosorbent assay. Chemiluminescence immunoassay was used to detect serum Hcy concentration. Plasma ADMA and serum Hcy level were compared between groups. The correlation between plasma ADMA and serum Hcy level was analyzed. Results The levels of plasma ADMA in mild and severe preeclampsia were significantly higher than those in control group (P <0.05, P <0.01). The levels of Hcy in mild and severe preeclampsia were significantly higher than those in control group There was statistical significance (all P <0.05). Pearson correlation analysis showed that there was a positive correlation between plasma ADMA level and Hcy level (r = 0.813, P <0.000). Linear stepwise regression analysis showed that the level of plasma ADMA increased with the increase of serum Hcy level, showing a linear trend (β = 9.453, P <0.01). Conclusions The levels of plasma ADMA and serum Hcy in preeclampsia are both elevated, which may be related to the occurrence and development of preeclampsia. Both ADMA and Hcy may be risk factors of preeclampsia.