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骨质疏松是骨强度受到损害而致骨折风险增加的骨骼疾病,可严重降低患者的生活质量与健康状况。导致药源性骨质疏松的常见药物包括口服抗凝药、钙调磷酸酶抑制剂、强效利尿药、质子泵抑制剂、噻唑烷二酮类降糖药、芳香酶抑制剂、蛋白酶抑制剂、糖皮质激素和抗癫痫药等。致病机制为药物通过促进骨吸收、抑制骨形成、抑制骨矿化影响正常骨代谢。骨密度测定可用于诊断药源性骨质疏松。防治药源性骨质疏松的有效措施包括合理用药,定期监测骨密度,缩短用药疗程,给予患者钙剂、维生素D制剂、双膦酸盐类药物、降钙素、选择性雌激素受体调节剂等药物治疗。
Osteoporosis is a skeletal disease that is impaired in bone strength and increases the risk of fracture, and can seriously impair the quality of life and health of patients. Common drugs that cause drug-induced osteoporosis include oral anticoagulants, calcineurin inhibitors, potent diuretics, proton pump inhibitors, thiazolidinedione hypoglycemic agents, aromatase inhibitors, protease inhibitors , Glucocorticoids and antiepileptic drugs. Pathogenesis of drugs through the promotion of bone resorption, inhibition of bone formation, inhibition of bone mineralization affect the normal bone metabolism. Bone mineral density determination can be used to diagnose drug-induced osteoporosis. Effective measures for the prevention and treatment of drug-induced osteoporosis include rational drug use, regular monitoring of bone mineral density, shortening of course of treatment, administration of calcium, vitamin D preparations, bisphosphonates, calcitonin, selective estrogen receptor regulation Agents such as drug treatment.