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目的研究乐果中毒大鼠对肝脏损害及不同剂量氯磷定治疗对其的影响。方法对180只大鼠分别给予盐水灌胃、中毒不治疗、阿托品治疗及大、中、小剂量氯磷定+阿托品治疗,观察其治疗后临床表现,通过丙氨酸氨基转移酶(ALT)值观察其肝损害程度。结果乐果染毒后未治疗组大鼠很快出现流涎、肌肉颤动、呼吸困难、抽搐,最后因呼吸衰竭死亡。给予氯磷定+阿托品组均比同等剂量单用阿托品治疗组症状轻,恢复快(P<0.01),大剂量氯磷定+阿托品组比中小剂量组症状轻、恢复快(P<0.01),中剂量氯磷定+阿托品组比小剂量组恢复快(P<0.01),各染毒组ALT均出现明显升高。各治疗组ALT在第6天达到高峰,阿托品组ALT峰值最高,然后依次为小剂量组及中等剂量组和大剂量组。结论急性乐果中毒,存在肝功能的损害。治疗量肟类复能剂本身不加重肝功损害,肟类化合物是治疗乐果中毒必不可少的药物。
Objective To study the effects of dimethoate poisoning on liver damage and the effects of different doses of chlorpromazine in rats. Methods 180 rats were given intragastric administration of saline, untreated poisoning, atropine treatment and large, medium and small doses of chlorfluazurin + atropine treatment, the clinical manifestations were observed after treatment by alanine aminotransferase (ALT) value Observe the degree of liver damage. Results dimethoate exposure to untreated rats soon appeared salivation, muscle fibrillation, breathing difficulties, convulsions, and finally died of respiratory failure. Compared with the same dose of atropine group, the symptoms of the treatment with chlorfluazurin and atropine were lighter and recovered faster (P <0.01). The symptoms of the high dose chloroprofen + atropine group were lighter and recovered faster (P <0.01) The middle dose of chlorophosphorus + atropine group recovered faster than the low dose group (P <0.01), and the ALT of each dose group increased obviously. The ALT peaked on day 6 in each treatment group, and the highest ALT peak in the atropine group, followed by the low-dose group, the middle-dose group, and the high-dose group. Conclusion Acute dimethoate poisoning has the damage of liver function. Treatment of oxime agents itself does not increase liver damage, oxime compounds are essential for the treatment of dimethoate poisoning drugs.