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目的研究Runx3基因表达与胃癌发生、发展、临床病理特征及患者预后的关系。方法用免疫组织化学SP法,检测80例胃癌组织、20例正常胃黏膜及20例胃黏膜不典型增生组织的表达。结果①Runx3基因在胃癌中阳性表达率为35%,明显低于胃黏膜不典型增生组织60%及正常胃黏膜组织90%,差异具存统计学意义(P<0.05)。②Runx3基因阳性表达与胃癌组织病理分级、浸润深度、淋巴结转移、临床分期有关,而与患者的年龄、性别、肿瘤大小无关。结论 Runx3基因表达与胃癌的发生发展关系密切,可作为胃癌预后的参考指标。
Objective To study the relationship between Runx3 gene expression and the occurrence, development, clinicopathological features and prognosis of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of 80 cases of gastric cancer, 20 cases of normal gastric mucosa and 20 cases of gastric mucosa dysplasia. Results ① The positive rate of Runx3 gene in gastric cancer was 35%, which was significantly lower than 60% in gastric dysplasia and 90% in normal gastric mucosa. The difference was statistically significant (P <0.05). The positive expression of Runx3 was related to the histological grade, depth of invasion, lymph node metastasis and clinical stage in gastric cancer, but not with age, sex and tumor size. Conclusion Runx3 gene expression is closely related to the occurrence and development of gastric cancer, which can be used as a reference index for the prognosis of gastric cancer.