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为研究氧、异搏停、酚妥拉明，硝酸甘油、硫氨卓酮、硝苯砒啶和巯甲丙脯酸在２２６０ｍ高原对肺动脉压的影响，对２１８例心血管病人进行了３０５例次的上述药物的经心导管监测的肺动脉压降压效果观察。结果：吸１００％氧１０分钟对不同水平肺动脉压均显示有统计学意义的降压效应，下降幅度为０．１７～０．７ｋＰａ。肺动脉内注射异搏停１０ｍｇ，肺动脉内注射酚妥拉明１０ｍｇ，舌下含化硝酸甘油１ｍｇ和口服琉甲丙脯酸７５ｍｇ只对肺动脉压增高者显示有统计学意义的降压效应，异搏停下降幅度为０．３６～０．５ｋＰａ，酚妥拉明下降０．６３～０．８５ｋＰａ，硝酸甘油下降０．４６～１．２１ｋＰａ，巯甲丙脯酸下降０．５６～０．９４ｋＰａ。异搏停、酚妥拉明、硝酸甘油和巯甲丙脯酸对肺动脉压正常者虽显示降压作用，但无统计学意义。口服硫氮卓酮１２０ｍｇ和口服硝苯吡啶３０ｍｇ对不同水平肺动脉压均未显示有统计学意义的降压效应。结论：吸氧、静注酚妥拉明、舌下含化硝酸甘油或口服巯甲丙脯酸可在２２６０ｍ高原较明显地降低肺动脉压。
To investigate the effect of oxygen, verapamil, phentolamine, nitroglycerin, thioamoxone, nifedipine and captopril on pulmonary arterial pressure at a plateau of 2260 m, 305 patients with 218 cardiovascular patients Times of these drugs observed by cardiac catheterization of pulmonary arterial pressure hypotensive effect. Results: 100% oxygen for 10 minutes on different levels of pulmonary arterial pressure showed a statistically significant antihypertensive effect, a decrease of 0.17 ~ 0.7kPa. Pulmonary artery injection of isosorbide 10mg, intra-pulmonary injection of phentolamine 10mg, sublingual nitroglycerin 1mg and oral carbamazine 75mg only increased pulmonary hypertension showed statistically significant antihypertensive effect, Stop the decline of 0.36 ~ 0.5kPa, phentolamine decreased 0.63 ~ 0.85kPa, nitroglycerin decreased 0.46 ~ 1.21kPa, Captopril decreased 0.56 ~ 0.94kPa. Verapamil, phentolamine, nitroglycerin and captopril on pulmonary arterial pressure despite the normal blood pressure showed an effect, but not statistically significant. Oral oral administration of diltiazem 120mg and oral nifedipine 30mg different levels of pulmonary arterial pressure showed no statistically significant antihypertensive effect. CONCLUSION: Pneumoconiosis was significantly reduced at 2260 m plateau by oxygen inhalation, intravenous injection of phentolamine, sublingual nitroglycerin, or oral captopril.