晚期癌症患者呼吸困难的发生率为29％～74％,是患者感到最痛苦的病症之一。晚期癌症呼吸困难的通常原因为限制性肺衰竭。作者应用前瞻性双盲交叉研究,评价氧疗对晚期癌症患者低氧血症性呼吸困难的作用。 107例具有呼吸困难的癌症患者,对其中14例(8例男性,6例女性)晚期伴有低氧血症癌症患者进行研究。中位年龄为64岁(49～79岁),所有病人经抗肿瘤治疗无效,感知功能正常,氧饱和度<90％,无COPD病史。 The incidence of dyspnea in patients with advanced cancer is 29% to 74%, which is one of the most painful conditions the patient feels. The usual cause of dyspnea in advanced cancer is restrictive lung failure. The authors used a prospective, double-blind crossover study to evaluate the effect of oxygen therapy on hypoxemic dyspnea in patients with advanced cancer. In 107 cancer patients with dyspnea, 14 patients (8 males and 6 females) with advanced cancer associated with hypoxemia were studied. The median age was 64 years old (49-79 years old). All patients had no response to anti-tumor therapy, normal sensory function, oxygen saturation < 90%, and no history of COPD.