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目的 制定脑血管病主要危险因素的定量评价标准。方法 通过文献检索收集脑血管病的危险因素、病例对照和队列研究资料 ,收集四川省的行为危险因素监测资料 ,运用系统评价数据库软件 (ReviewManager 4 .1.1)进行Meta分析 ,将各研究的危险因素与脑血管病的比值比 (OR)、相对危险度 (RR)进行合并 ,以合并的OR(RR)值为基础 ,运用统计模型将不同暴露水平的危险因素转换为危险分数。结果 以 5岁为一个年龄组 ,建立了 35～ 6 9岁分性别的脑血管病主要危险因素 :吸烟、被动吸烟、高血压、高血脂、体重指数、体育锻炼、饮酒、高脂饮食、喝奶、口服避孕药、糖尿病史、心脏病史和脑卒中家族史的定量评价标准 (危险分数转换表 )。无这些危险因素 (体育锻炼、喝奶除外 )者其危险分数均≤ 1.0 0 ,而有这些危险因素者其危险分数均 >1.0 0 ,且危险分数随危险程度的增加而增高。结论 脑血管病危险分数转换表是计算脑血管病存在死亡危险的基础 ,后者可预测个体在未来 10年发生脑血管病死亡的概率。
Objective To develop a quantitative evaluation criteria of the main risk factors of cerebrovascular disease. Methods The risk factors of cerebrovascular disease, case control and cohort study data were collected through literature search. The monitoring data of behavioral risk factors in Sichuan Province were collected and analyzed by Meta-analysis using the reviewing database (ReviewManager 4.1.1). The risk factors (OR) and relative risk (RR) of cerebrovascular diseases. Based on the combined OR (RR) values, statistical models were used to convert the risk factors of different exposure levels into risk scores. Results A 5-year-old age group established the main risk factors of cerebrovascular disease between 35 and 69 years old: smoking, passive smoking, hypertension, hyperlipidemia, body mass index, physical exercise, drinking, high fat diet, drinking Milk, Oral Contraceptives, Diabetes, Heart Disease, and Family History of Stroke Quantitative Evaluation Criteria (Hazard Score Conversion Table). Without these risk factors (except physical exercise and drinking milk), the risk scores were all ≤ 1.0 0, while those with risk factors were all> 1.0 0, and the risk scores increased with the increase of the risk level. Conclusions The CSF conversion table is the basis for calculating the risk of death from cerebrovascular disease, which predicts the probability of death from cerebrovascular disease in the next 10 years.