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2-硝基亚甲基噻唑烷(1)是合成雷尼替丁侧链及其他杂环、稠环化合物的中间体,系由1,1-二甲硫基-2-硝基乙烯(2)和盐酸2-巯基乙胺(3)反应制得。德国专利以水和乙醇为溶剂回流反应,经浓缩加甲醇析
2-Nitromethylenethiazolidine (1) is an intermediate for the synthesis of ranitidine side chains and other heterocyclic and fused ring compounds, and is synthesized from 1,1-dimethylthio-2-nitroethylene ) And 2-mercaptoethylamine hydrochloride (3). German patent water and ethanol as the solvent reflux reaction, concentrated by methanol plus