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Fe_3O_4磁性纳米粒子由于其良好的磁学性能,被广泛应用到了化学、生物、物理、环境保护等各个领域。尤其是在生物医学领域中的应用越来越受到研究者的关注。由于其所具有的优秀的超顺磁性性质,Fe_3O_4磁性纳米粒子可以作为造影剂,增强核磁共振成像的对比度和成像效果;也可以结合到纳米载药系统内用于药物的靶向输送;也可以包埋到蛋白内部用于蛋白的磁性分离;也可以用于基因治疗,提高靶细胞的转染效率;由于其在近红外光的作用下具有很好的光热转换效果,使温度升高,展现出的良好热疗效果,Fe_3O_4磁性纳米粒子又可以用于癌细胞的热疗。本文针对其在该领域中作为药物的靶向传递,蛋白的磁分离,核磁共振成像,热疗,以及基因治疗的载体等方面的研究应用进行了系统性的总结,阐述了Fe_3O_4磁性纳米粒子在生物医学领域中各种应用进展和优势。
Due to its good magnetic properties, Fe_3O_4 magnetic nanoparticles are widely used in various fields such as chemistry, biology, physics and environmental protection. Especially in the field of biomedical applications more and more researchers attention. Due to its excellent superparamagnetic properties, Fe 3 O 4 magnetic nanoparticles can be used as contrast agents to enhance the contrast and imaging performance of magnetic resonance imaging. It can also be incorporated into the drug delivery system for targeted delivery of drugs. Embedded into the protein for magnetic separation of proteins; can also be used for gene therapy to improve the transfection efficiency of target cells; due to its role in the near-infrared light has a good light-heat conversion effect, the temperature increase, Showing good effect of hyperthermia, Fe_3O_4 magnetic nanoparticles can be used for cancer cell hyperthermia. In this paper, we systematically summarize its applications in the field of targeted delivery of drugs, magnetic separation of proteins, magnetic resonance imaging, hyperthermia, and gene therapy vectors, and described the application of Fe 3 O 4 magnetic nanoparticles in Advances and Advantages of Various Applications in the Biomedical Field.