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正常细胞的分裂次数是有上限的,最终它们的分裂会永久性地停滞或者死亡.然而肿瘤细胞则与之截然不同,来自Salk生物研究学院的研究揭示了肿瘤永生化的又一重要机制.这篇发表在2011年4月22日刊出的Molecular Cell上的研究报道发现了一个染色体末端的新结构,它是调控细胞寿命的重要元件,以它为化疗靶点从而缩短肿瘤细胞寿命成为治疗肿瘤的又一新方向.
The number of normal cell divisions is capped, and eventually their division permanently stalls or dies, whereas tumor cells are quite different, and a study from the Salk Institute for Biological Research reveals yet another important mechanism of tumor immortality. Published in the April 22, 2011 article in the Molecular Cell report found a new structure of chromosome ends, it is an important component of the regulation of cell life, use it as a chemotherapy target to shorten the life of tumor cells to become tumor Another new direction.