以香兰素、异香兰素、间溴苯甲醛和对溴苯甲酸甲酯为原料,通过Ullmann反应、醛基与酚羟基的保护和脱保护、醛基还原、磷盐生成、Wittig反应以及烯烃的催化氢化反应等方法完成了新地钱素A的全合成。所得化合物的结构通过MS、~1HNMR进行确证。采用MTT法测试目标化合物体外抗肿瘤(A549、MCF-7、U20S)活性。结果表明,新地钱素A对A549和MCF-7表现出较好的抑制活性。 With vanillin, isovanillin, m-bromobenzaldehyde and p-bromobenzoate as raw materials, Ullmann reaction, the protection and deprotection of aldehyde group and phenolic hydroxyl group, the reduction of aldehyde group, the formation of phosphorescent salt, the Wittig reaction, The catalytic hydrogenation reaction and other methods to complete the new synthesis of the new metylamine. The structure of the obtained compound was confirmed by MS, ~ 1HNMR. The target compounds were tested for anti-tumor (A549, MCF-7, U20S) activity in vitro using MTT assay. The results showed that the new melatonin A A549 and MCF-7 showed good inhibitory activity.