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目的观察新疆曼陀罗子(生品、提取物)及其代表制剂镇痛艾比西帕丸对大鼠抗氧化指标的影响。方法选用SD大鼠,随机分为空白对照组(0.5%羟甲基纤维素钠)、曼陀罗子提取物组(每kg含生药1.55,3.10,6.20 g)、曼陀罗子生品组(每kg含生药3.1 g)、曼陀罗子代表制剂镇痛艾比西帕丸组(成品组,每kg含生药2 g),每100 g体重1 mL连续灌胃大鼠90 d,分别观察在给药90 d和停药15 d后大鼠肝、脑、肾组织匀浆单胺氧化酶(MAO)、乙酰胆碱酯酶(TChE)指标。结果与对照组比较,给药组对大鼠肝、脑、肾组织匀浆MAO、TCHE影响虽有统计学差异,但其差异没有剂量和时间规律性。结论在规定的时间和剂量范围内,新疆曼陀罗子及其代表制剂镇痛艾比西帕丸对大鼠肝、脑、肾组织匀浆MAO及TChE无明显影响。
Objective To observe the effects of Anti-angioedesis of Anti-anguillarum, a traditional Chinese medicine, of Datura manchurianus (raw products, extracts) and its representative preparation. Methods SD rats were randomly divided into blank control group (0.5% sodium carboxymethyl cellulose), Mandragora extract group (1.55, 3.10 and 6.20 g per kg crude drug) kg containing crude drug 3.1 g), Mandraro child represented analgesic and epigastric pill group (finished product group, containing 2 g crude drug per kg), rats were fed with 1 mL per 100 g body weight for 90 days, Administration of monoamine oxidase (MAO) and acetylcholinesterase (TChE) in rat liver, brain and kidney homogenate after 90 d of drug administration and 15 days of drug withdrawal. Results Compared with the control group, the effects of the administration group on the MAO and TCHE in the liver, brain and kidney homogenate of rats were statistically different, but the differences were not dose and time regularity. Conclusion The mandibular drug exertion and its representative formulation of Epimedium-Semettii in Xinjiang did not affect the homogenate MAO and TChE in the liver, brain and kidney of rats within the prescribed time and dose range.