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目的:了解反复自然流产和不孕症者与抗心磷脂抗体(ACA-IgG)、抗滋养层细胞膜抗体(TA-Ab)、抗卵细胞透明带抗体(ZP-Ab)之间的关系。方法:对反复自然流产和不孕症者血清ACA、TA、ZP抗体进行检测分析。结果:反复自然流产组62例中17例ACA-IgG阳性,阳性率为27.42%,明显高于不孕症及对照组(χ2=15.04,P<0.01);TA-Ab测定在不孕症组为25.00%,反复自然流产组为39.24%,阳性率明显高于对照组(χ2=10.53,P<0.01);ZP-Ab测定结果,不孕症组阳性率为19.35%,反复自然流产组为15.00%,明显高于对照组(χ2=5.96,P<0.05)。结论:对于不明原因的反复自然流产者和不孕症应适时检测ACA-IgG、TA-Ab、ZP-Ab,对临床诊断和指导治疗有其积极的应用价值。
Objective: To investigate the relationship between ACA-IgG, TA-Ab and ZP-Ab in patients with recurrent spontaneous abortion and infertility. Methods: Serum ACA, TA, ZP antibodies in patients with recurrent spontaneous abortion and infertility were detected. Results: 17 cases of recurrent spontaneous abortion group of 62 cases of ACA-IgG positive, the positive rate was 27.42%, significantly higher than the infertility and control group (χ2 = 15.04, P <0.01); TA-Ab determination in infertility group (Χ2 = 10.53, P <0.01). The positive rate of ZP-Ab in infertility group was 19.35%. The rate of recurrence of spontaneous abortion group was significantly higher than that of control group 15.00%, significantly higher than the control group (χ2 = 5.96, P <0.05). CONCLUSION: ACA-IgG, TA-Ab and ZP-Ab should be detected timely for patients with unexplained recurrent spontaneous abortion and infertility. It has positive application value in clinical diagnosis and treatment.