目的：建立肠必清肠溶颗粒剂的质量控制方法。方法：参照《中国药典》类似制剂的质量要求，对本品的质量进行了全面检测，并用薄层色谱法对本品的番泻苷Ａ 和橙皮苷进行定性鉴别，用比色法对总番泻苷进行含量测定。结果：本品的粒度、水分、释放度等均符合规定。薄层定性方法斑点清晰， 分离完全， 易于区别。含量测定方法精密度 ＜ １－６ ％ ， 平均回收率为９７－４０ ％ （ＲＳＤ ＝１－０６ ％ ，ｎ ＝ ５） 。结论：本文所建立的定性及定量方法准确、可靠，重现性好，可作为该制剂的质量控制方法。 Objective: To establish a quality control method for intestinal granules. Method: According to the quality requirements of similar preparations of the Chinese Pharmacopoeia, the quality of this product was comprehensively tested, and the qualitative identification of the product of sennoside A and hesperidin was performed by thin layer chromatography. The sennoside was assayed for content. Result: The particle size, moisture, and release of the product are in compliance with the regulations. The thin layer qualitative method has clear spots, complete separation, and easy distinction. The precision of the determination method was < 1-6 %, and the average recovery was 97-40 % (RSD =1-06 %, n = 5). Conclusion: The qualitative and quantitative methods established in this paper are accurate, reliable, and reproducible, and can be used as quality control methods for the preparation.