论文部分内容阅读
异名 Dipentum,Azodisal Disodium 化学名 4,4′-二羟基偶氮苯-3,3′二羧基钠或5,5′偶氮二水杨酸钠药效分类抗溃疡性结肠炎药开发单位 (瑞典)Pharmacia AB 上市厂商 (丹麦)Pharmacia Ltd1987年药理作用治疗溃疡性结肠炎的常用药物为柳氮磺吡啶,其不良反应发生率约有20%,使不少病例须减量或中止使用。柳氮磺吡啶在结肠经结肠细菌裂解成5-氨基水杨酸和磺胺吡啶,并已证实磺胺吡啶为无效和产生副作用的部分。5-氨基水杨酸为治疗活性部分,它可抑制引起炎症的PG_s的合成与能抑制能引起水肿,增强细胞膜渗透性的炎
Synonyms Dipentum, Azodisal Disodium Chemical name 4,4’- dihydroxyazobenzene-3,3 ’dicarboxyl sodium or 5,5’ sodium azodicarboxylate Pharmacodynamic classification Anti-ulcerative colitis drug development unit ( Sweden) Pharmacia AB Listed manufacturer (Denmark) Pharmacia Ltd 1987 Pharmacokinetics of anti-proliferative drugs The prevalence of illicit drugs is about 20% in Adhivas, resulting in a reduction or discontinuation of many cases. Sulphasalazine is cleaved in the colon by colon bacteria to 5-aminosalicylic acid and sulfapyridine and sulfapyridine has been shown to be ineffective and have side effects. 5-Aminosalicylic acid is a therapeutically active moiety that inhibits the synthesis of PGs that cause inflammation and inhibits inflammation that causes edema and enhances cell membrane permeability