Hippo信号通路最初发现在果蝇中,对多细胞动物的细胞增殖、凋亡和器官大小进行调节〔1-3〕。从Hippo/Mst到YAP/Yki磷酸化核心激酶级联反应相比,Hippo激酶级联上游的蛋白反应很少被研究。在果蝇的早期研究已经表明,顶端膜联FERM域蛋白Merlin与其扩展可能作为信号通路元件Hippo通路的上游〔4〕。近年来越来越多的研究表明Merlin蛋白与肿瘤的发生关系密切,作为 Hippo signaling pathway was originally found in Drosophila, multi-cellular animal cell proliferation, apoptosis and organ size [1-3]. The protein response upstream of the Hippo kinase cascade has rarely been investigated compared to the YAP / Yki phosphorylated core kinase cascade from Hippo / Mst. Early studies in Drosophila have shown that the apical membrane-linked FERM domain protein Merlin and its extensions may serve as upstream of the Hippo pathway of the signaling pathway element [4]. In recent years, more and more studies show that Merlin protein is closely related to tumorigenesis