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目的 探讨绝经后妇女原发性高血压 (EH)患者性激素水平变化及与胰岛素抵抗的关系。方法 对 3 3例绝经 1年以上妇女原发性高血压患者 (A组 )、2 1例绝经 1年以上无高血压健康妇女 (B组 )的血清雌二醇 (E2 )、孕酮 (P)、睾酮(T)、血浆葡萄糖 (G)、血浆胰岛素 (INS)及胰岛素敏感指数 (ISI)进行检测。结果 A组E2 水平较B组明显降低 ,P水平显著增高。相关分析发现 ,E2 与INS呈显著负相关 ,而E2 与ISI呈显著正相关 ;P与INS呈显著正相关 ,与ISI呈显著负相关。结论 绝经后妇女原发性高血压患者存在严重的性激素失调 ,且与胰岛素抵抗并存 ,可能参与绝经后妇女原发性高血压的发生和发展。
Objective To investigate the relationship between sex hormone levels and insulin resistance in postmenopausal women with essential hypertension (EH). Methods Serum estradiol (E2) and progesterone (P) were measured in 33 women with essential hypertension at more than one year (group A), 21 women with hypertension at least one year after menopause (group B) ), Testosterone (T), plasma glucose (G), plasma insulin (INS) and insulin sensitivity index (ISI). Results The E2 level in group A was significantly lower than that in group B, and the level of P was significantly increased. Correlation analysis showed that there was a significant negative correlation between E2 and INS, while E2 was positively correlated with ISI. P was positively correlated with INS and negatively correlated with ISI. Conclusions There are severe sex hormone disorders in postmenopausal women with essential hypertension and may coexist with insulin resistance, which may be involved in the occurrence and development of essential hypertension in postmenopausal women.