C-5甲基氟喹诺酮(OPC-17116)是一种新的氟喹诺酮类药,它的化学结构见下图: 已有实验证明OPC-17116在体外对肺炎链球菌有极强的抗菌活性,抑制90%分离菌的浓度≤0.5μg/ml,超过目前常用的环丙沙星和氧氟沙星。本实验测定了OPC-17116对部分常见病原菌的血浆杀菌活性。8名正常健康的男性志愿者在禁食情况下每24h一次服用OPC C-5 methyl fluoroquinolone (OPC-17116) is a new fluoroquinolone drug whose chemical structure is shown in the following figure: It has been proved by experiments that OPC-17116 has strong antibacterial activity against S. pneumoniae in vitro, Inhibition of 90% of the concentration of isolates ≤ 0.5μg / ml, more than currently used ciprofloxacin and ofloxacin. In this experiment, we measured the plasma bactericidal activity of OPC-17116 on some common pathogens. Eight healthy, normal, male volunteers took OPC every 24 hours during fasting