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为研究边缘型维生素Ａ缺乏（ＭＶＡＤ）对大鼠红系细胞膜Ｎ连接型糖链（Ｎ糖链）的影响，采用系列凝集素柱层析法，并配合外切糖苷酶，研究ＭＶＡＤ对红系细胞分化过程中细胞膜Ｎ糖链的影响，结果显示，ＭＶＡＤ引起大鼠红系细胞膜Ｎ糖链合成减少，复杂型糖链下降，高甘露糖型及杂合型糖链上升；天线数无变化；复杂型糖链中不含分叉型Ｎ乙酰氨基葡萄糖（Ｂ－Ｇｎ）及核心岩藻糖（Ｃ－Ｆｕｃ）组分下降，含Ｂ－Ｇｎ或Ｃ－Ｆｕｃ或同时含Ｂ－Ｇｎ和Ｃ－Ｆｕｃ组分增加，提示ＭＶＡＤ减少Ｎ糖链合成，阻碍糖链向成熟方向转化，使Ｎ糖链趋于较不成熟和分化较差，是细胞分化障碍的标志，它可能与细胞受体功能有关。
In order to study the effect of marginal vitamin A deficiency (MVAD) on N-linked glycans (N-linked glycans) of rat erythrocyte membrane, a series of lectin column chromatography and exo-glycosidase were used to study the effect of MVAD on erythroid The results showed that MVAD caused a decrease of synthesis of N-linked glycans in rat erythrocyte membrane, a decrease of complex type of oligosaccharide chain, a rise of high-mannose type and heterozygous type of oligosaccharide chain; no change in number of antennae; Complex carbohydrate chains without branched N-acetylglucosamine (B-Gn) and core fucose (C-Fuc) components decreased, with B-Gn or C-Fuc or both B-Gn and C- The increase of Fuc components suggested that MVAD could reduce the synthesis of N-linked sugar chains, hinder the transformation of sugar chains to mature orientation, make N-linked sugar chains less mature and poorly differentiated, which is a sign of cell differentiation disorder, which may be related to cell receptor function .