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[病例1]女,18y.因偶发分枝杆菌感染入院.由于偶发分枝杆菌为条件致病菌,属结核杆菌类,又经药敏试验该菌对氧氟沙星敏感,故予氧氟沙星注射液100ml(广东彼迪药业有限公司,批号99011403)iv gtt,bid,同时po抗痨药(异烟肼0.3gqd,利福平0.45 gqd,乙胺丁醇0.5 g tid,吡嗪酰胺0.5 g tid等)进行综合治疗.首次计iv gtt约20 ml(30滴/min)时,左手背进针处局部出现红肿,面积大约4cm×5cm.红肿处高出正常皮肤表面约1mm,沿着血管走向左前臂有散在的暗红色米粟样大小的皮疹.左手臂瘙痒,但能忍受.输液完毕后5h 内瘙痒消失,10h内局部红肿逐渐褪去.次日,为排除po药物的影响,决定停服抗痨药2d,继续iv gtt氧氟沙星也出现同样症状.d 3当输入液体约10ml时,除出现上述症状外,全身都出现瘙痒症状,且左手静脉沿回心方向产生烧灼痛,继之静脉周围明显水肿,有压痛感.立即停药,瘙痒、静脉烧灼痛10h内消失;
[Case 1] Female, 18y. Admitted to the hospital because of occasional mycobacterial infection due to the incidental Mycobacterium tuberculosis bacteria are opportunistic bacteria, but also susceptibility test susceptible to ofloxacin, so the oxygen fluoride Shaoxing injection 100ml (Guangdong Petty Pharmaceutical Co., Ltd., batch number 99011403) iv gtt, bid, while po anti-tuberculosis drugs (isoniazid 0.3gqd, rifampin 0.45 gqd, ethambutol 0.5g tid, pyrazine Amide 0.5 g tid, etc.) for the first time about iv gtt about 20 ml (30 drops / min), the left back into the needle at the local redness, an area of about 4cm × 5cm. Inflammation above the normal skin surface about 1mm, Along the blood vessels to the left forearm with scattered dark red millet-like rash left arm itch, but can endure it 5h after infusion disappeared within 10h local redness gradually faded the next day, in order to rule out the impact of po drugs , Decided to stop taking anti-tuberculosis drugs 2d, to continue iv gtt ofloxacin also appear the same symptoms .d 3 when the input liquid about 10ml, in addition to the above symptoms, the whole body have symptoms of pruritus, and left venous along the heart direction Burning pain, followed by significant edema around the veins, tenderness immediately stop the itching, burning within 10h of the veins disappeared;