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目的观察双环醇治疗药物性肝病的疗效。方法对2008年1月～2009年12月贵阳医学院附属医院收治的39例药物性肝病患者,分别使用双环醇片和注射用还原型谷胱甘肽进行治疗。观察两种药物治疗前后ALT、AST、γ-GGT和TBiL的变化情况。结果两组患者治疗前后组间比较,ALT、AST、γ-GGT和TBiL 4项生化指标都有所下降,差异有统计学意义(P<0.01)。与对照组相比,治疗组治疗后ALT和γ-GGT下降较为明显,差异有统计学意义(P<0.05)。结论使用双环醇治疗药物性肝病,能加快病情的恢复,疗效较肯定。
Objective To observe the efficacy of bicyclol in the treatment of drug-induced liver disease. Methods From January 2008 to December 2009, 39 cases of drug-induced liver disease in Guiyang Medical College Affiliated Hospital were treated with bicyclol tablets and glutathione for injection respectively. The changes of ALT, AST, γ-GGT and TBiL before and after treatment with two drugs were observed. Results The biochemical indexes of ALT, AST, γ-GGT and TBiL decreased in both groups before and after treatment, the difference was statistically significant (P <0.01). Compared with the control group, the treatment group after treatment ALT and γ-GGT decreased more significantly, the difference was statistically significant (P <0.05). Conclusion Bicyclol treatment of drug-induced liver disease can speed up the recovery of the disease, the effect is more certain.