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目的探讨皮肤假血管瘤样鳞状细胞癌的临床病理特点。方法对1例发生于皮肤的假血管瘤样鳞状细胞癌的临床表现、组织形态、组织化学、免疫组化及电镜进行分析,并复习相关文献。结果患者女性,85岁。临床表现为右下腹皮肤暗红色包块。镜下肿瘤细胞轻度异型,呈血管瘤样结构排列。免疫组化显示肿瘤细胞CK(AE1/AE3)和CK14强(+),CD34、CD31和FⅧ(-)。Gomori氏网织纤维染色显示单个肿瘤细胞周边(-)。电镜下肿瘤细胞间桥粒连接,细胞质内可见张力丝。结论免疫组化、电镜及临床表现是正确诊断皮肤假血管瘤样鳞状细胞癌的重要依据。
Objective To investigate the clinical and pathological features of cutaneous pseudoangioma-like squamous cell carcinoma. Methods The clinical manifestations, histomorphology, histochemistry, immunohistochemistry and electron microscopy of 1 case of pseudohemaggioid squamous cell carcinoma of the skin were analyzed and related literatures were reviewed. Results Female patient, 85 years old. Clinical manifestations of the right lower abdomen skin dark red mass. Microscopic tumor cells were mild atypia, showing a hemangio-like structure. Immunohistochemistry showed that CK (AE1 / AE3) and CK14 (+), CD34, CD31 and FⅧ (-) of tumor cells were positive. Gomori's reticulocyte staining showed the periphery of individual tumor cells (-). Under electron microscope, the desmosomes are connected with tumor cells, and the tension filaments can be seen in the cytoplasm. Conclusion Immunohistochemistry, electron microscopy and clinical manifestations are the important evidences for correctly diagnosing squamous cell carcinoma of the skin.