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抗原不管是经鼻、气管、或皮肤进入过敏性病人体内均可发生速发型反应。但某些病人尽管无抗原的二次攻击,也会在速发型反应的数小时内又发生第二次反应。即缓发型反应。许多作者已观察到在皮肤、肺和鼻粘膜发生的这种反应。因速发型反应尚不能完全解释过敏性鼻炎、哮喘的临床表现,故对缓发型反应的研究愈来愈受到重视。作者为研究缓发型过敏性鼻炎的发病机制,以花粉抗原对12名过敏性鼻炎患者行鼻内激发试验,以症状打分法记录其临床表现,并同时测定鼻灌洗液中的四种生化介质:组胺,TAME-酯酶(甲苯磺酰-L-精氨酸甲酯-酯酶),激肽和前列腺素D_2(PGD_2)。结果有9人在发生速发型反应后3～11小时内又发生缓发型反应,抗原攻击前症状得分为1.2±0.3,发生速发反应时为9.3±1.1,间歇静止期为3.0±1.2,缓发型反应期则为5.7±0.9。在
Whether antigens through the nose, trachea, or skin into the allergic patients can occur rapid reaction. However, some patients, despite the second attack without antigen, will have a second reaction within a few hours of rapid response. The slow reaction. Many authors have observed this response to occur in the skin, lungs and nasal mucosa. Due to the rapid onset of response can not yet fully explain the clinical manifestations of allergic rhinitis, asthma, so the study of delayed response more and more attention. In order to study the pathogenesis of allergic rhinitis, 12 allergic rhinitis patients were challenged intranasally with pollen antigen, and their clinical manifestations were recorded by symptom score. Simultaneously, four biochemical mediators : Histamine, TAME-esterase (tosyl-L-arginine methyl ester-esterase), kinin and prostaglandin D_2 (PGD_2). The results showed that 9 patients developed a slow response within 3 to 11 hours after the onset of immediate onset reaction. The score before symptom onset was 1.2 ± 0.3, 9.3 ± 1.1 at onset of fasting, and 3.0 ± 1.2 at rest. Hair type reaction period was 5.7 ± 0.9. in