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目的探讨血必净注射液对炎症的影响及治疗脓毒症患者的临床疗效。方法检索各大数据库,查找血必净治疗脓毒症的相关临床试验,并采用RevMan 5.0进行Meta分析。结果共纳入4项随机对照临床试验,治疗组181例患者给予血必净+乌司他丁+基础治疗,对照组181例患者给予乌司他丁+基础治疗。Meta分析结果显示,治疗组患者与对照组患者的肿瘤坏死因子(TNF-α)水平比较,差异无统计学意义(WMD=-5.16,95%CI:-11.0~0.76);治疗组患者与对照组患者在白细胞介素-6(IL-6)水平(WMD=-57.82,95%CI:-112.12~-3.52)、降钙素原(PCT)水平(WMD=-0.53,95%CI:-0.88~-0.19)、平均住院时间(WMD=-3.63,95%CI:-4.68~-2.58)、平均机械通气时间(WMD=-3.77,95%CI:-4.70~-2.83)比较,差异均有统计学意义。结论应用血必净患者的白细胞介素-6(IL-6)、前降钙素(PCT)水平更低,平均住院时间、平均机械通气时间更短。
Objective To investigate the effect of Xuebijing injection on inflammation and the clinical effect of treating sepsis. Methods The major databases were searched to find out the clinical trials of Xuebijing in the treatment of sepsis. Meta-analysis was performed using RevMan 5.0. Results A total of 4 randomized controlled clinical trials were included. 181 patients in the treatment group received Xuebijing + ulinastatin + basic treatment, and 181 patients in the control group received ulinastatin + basic treatment. Meta analysis showed that there was no significant difference in the levels of tumor necrosis factor (TNF-α) between the treatment group and the control group (WMD = -5.16,95% CI: -11.0 ~ 0.76); the treatment group and the control group The levels of IL-6 (WMD = -57.82, 95% CI: -112.12 ~ -3.52) and procalcitonin (PCT) 0.88 ~ -0.19), mean length of stay (WMD = -3.63, 95% CI: -4.68 ~ -2.58), mean mechanical ventilation time (WMD = -3.77, 95% CI: -4.70 ~ -2.83) There is statistical significance. CONCLUSIONS: The serum levels of interleukin-6 (IL-6), procalcitonin (PCT) in patients with XBD are lower, the average length of stay and the mean duration of mechanical ventilation are shorter.