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目的 探讨各期显症梅毒不同临床型的组织病理学特征。方法 对53例各期显症梅毒患者进行了临床病理学分析。结果 组织病理观察表明,血管内膜炎和以浆细胞为主的混合型炎细胞浸润为各期梅毒所共有。硬下疳病变中央部表皮缺损,真皮中上部或全层显示弥漫性混合性炎细胞浸润和明显血管内膜炎。浅表结节型三期梅毒表现为附属器周围和皮下脂肪小叶内限局性上皮样细胞肉芽肿,其间混有多核巨细胞。二期梅毒因皮损类型不同,组织像亦不尽一致。结论 硬下疳和二期梅毒基本病理改变为梅毒性亚急性炎症,结节型三期梅毒为上皮样细胞肉芽肿。
Objective To investigate the histopathological features of different clinical manifestations of syphilis at various stages. Methods Fifty-three patients with syndromic syphilis were analyzed clinically and pathologically. Results Histopathological examination showed that endometriosis and mixed inflammatory cell infiltration based on plasma cells were common to all stages of syphilis. Scleroderma Central lesion epidermis defects, the upper or middle dermis showed diffuse mixed inflammatory cell infiltration and significant endocarditis. Superficial nodular triple syphilis showed appendage around the subcutaneous fat lobular end of the local epithelioid cell granuloma, mixed with multinucleated giant cells. Secondary syphilis due to different types of lesions, like the tissue is not the same. Conclusions The basic pathological changes of the subdural syphilis and secondary syphilis are syphilitic subacute inflammation, and the third-stage nodular syphilis is epithelial-like granuloma.