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目的:现察中成药肾灵Ⅱ号对慢性肾功能衰竭(chronic renal failure,CRF)延缓的作用。方法:200例CRF患者分为两组,A组(自身对照组)100例,治疗分为两个阶段,第一阶段先用酚妥拉明10mg、多巴胺20mg、呋塞米60mg加入10％葡萄糖液250ml静滴,qd。第二阶段加用肾灵Ⅱ号治疗:B组100例,治疗方案与A组第二阶段相同。以计算血清肌酐倒数(dl/mg)与时间(月)的直接回归斜率评估CRF的进展速度。结果:A组第一阶段直线回归斜率均数为-0.0103±0.0020,A组第二阶段斜率均数为-0.0032±0.0016,两阶段比较有显著性差异(P<0.05);B组斜率均数为-0.0049±0.0020,与A组第一阶段比较有显著性差异(P<0.05)。结论:在利尿治疗的基础上加用肾灵Ⅱ号,可使CRF进展速度明显延缓。
Objective: To investigate the effect of Chinese patent medicine Shenling Ⅱ on the delay of chronic renal failure (CRF). Methods: Two hundred patients with CRF were divided into two groups. Group A (self-control group) with 100 cases. The treatment was divided into two stages. In the first stage, 10% of phentolamine, 20 mg of dopamine and 60 mg of furosemide were added into 10% Liquid 250ml intravenous infusion, qd. The second phase plus Shen Ling Ⅱ treatment: 100 cases in group B, treatment and A group of the second phase of the same. The rate of progression of CRF was assessed by calculating the direct regression slope of serum creatinine countdown (dl / mg) versus time (month). Results: The average linear regression slope of group A in the first stage was -0.0103 ± 0.0020, and the average of the second stage in group A was -0.0032 ± 0.0016 (P <0.05) Was -0.0049 ± 0.0020, which was significantly different from that of the first phase in group A (P <0.05). Conclusion: Based on diuretic treatment, the addition of Shenling Ⅱ can slow down the progression of CRF.