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一、概述 1,2-二氯乙烷(1,2-DCE)是一种工业上广泛使用的有机溶剂。大量用作制造氯乙烯单体,乙二胺和苯乙烯。一般以蒸气的形式存在于这些工业企业的车间空气中。二氯乙烷有两种异构体:1,2-DCE和1,1-DCE。据Hofmann等报道,1,2-DCE慢性毒性为1,1-DCE的5倍;Weisburger用大鼠和小鼠研究1,2-DCE和1,1-DCE的致癌作用时证实,1,2-DCE(100 mg/kg灌胃)可诱发大、小鼠肿瘤发生,而1,1-DCE(900 mg/kg灌胃)对大鼠无致肿瘤作用。可见它们之间毒性差别很大。由于塑料工业及化纤工业的迅速发展。特别是近年来对1,2-DCE毒理学研究的进展,并有实验证实它具有致突变、致胚胎毒及致癌性。因此,必须慎重对待1,2-DCE
I. Overview 1,2-Dichloroethane (1,2-DCE) is a widely used industrial organic solvents. A large number for the manufacture of vinyl chloride monomer, ethylenediamine and styrene. Generally exist in the form of steam in the workshop of these industrial enterprises in the air. There are two isomers of dichloroethane: 1,2-DCE and 1,1-DCE. According to Hofmann et al., The chronic toxicity of 1,2-DCE was 5-fold that of 1,1-DCE; Weisburger’s study of the oncogenic effects of 1,2-DCE and 1,1-DCE in rats and mice confirmed that 1,2 DCE (100 mg / kg intragastrically) induced tumor development in large and small mice, whereas 1,1-DCE (900 mg / kg) did not cause tumor in rats. Shows that the toxicity between them is very different. Due to the rapid development of the plastics industry and chemical fiber industry. Especially in recent years 1,2-DCE toxicology research progress, and experiments confirmed that it has mutagenicity, embryo toxicity and carcinogenicity. Therefore, 1,2-DCE must be treated with caution