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目的:探讨TROP2、p-Akt及vimentin在甲状腺乳头状癌中的表达及临床意义。方法:采用免疫组织化学方法检测76例甲状腺乳头状癌、36例甲状腺瘤组织、36例正常甲状腺组织中TROP2、p-Akt及vimentin的表达,并对性别、年龄、肿瘤大小、临床TNM分期及淋巴结转移等因素进行分析。结果 :76例甲状腺乳头状癌中TROP2、p-Akt及vimentin蛋白的阳性表达率分别为65.8%、68.4%、69.7%,与甲状腺瘤组织、正常甲状腺组织相比,差异均有统计学意义(P<0.05)。TROP2、p-Akt及vimentin蛋白在淋巴结转移组的阳性表达率均高于淋巴结无转移组(P<0.05);TROP2、p-Akt及vimentin蛋白在Ⅲ+Ⅳ期中的阳性表达率均明显高于Ⅰ+Ⅱ期(P<0.05)。经Spearman等级相关性分析表明,TROP2与p-Akt、vimentin的表达均呈正相关(r=0.313,P=0.038;r=0.402,P=0.031);p-Akt与vimentin的表达也呈正相关(r=0.464,P=0.026)。结论:TROP2的表达与甲状腺乳头状癌的恶性侵袭及转移有关,可作为靶向治疗甲状腺乳头状癌的潜在基因。
Objective: To investigate the expression and clinical significance of TROP2, p-Akt and vimentin in thyroid papillary carcinoma. Methods: The expressions of TROP2, p-Akt and vimentin in 76 cases of thyroid papillary carcinoma, 36 cases of thyroid tumor and 36 cases of normal thyroid tissue were detected by immunohistochemical method. The changes of sex, age, tumor size, clinical TNM stage, Lymph node metastasis and other factors for analysis. Results: The positive rates of TROP2, p-Akt and vimentin in thyroid papillary thyroid carcinoma were 65.8%, 68.4% and 69.7%, respectively, which were significantly different from that of thyroid adenoma and normal thyroid tissues P <0.05). The positive expression rates of TROP2, p-Akt and vimentin in lymph node metastasis group were higher than that in lymph node non-metastasis group (P <0.05). The positive rates of TROP2, p-Akt and vimentin in stage Ⅲ + Ⅳ were significantly higher Ⅰ + Ⅱ (P <0.05). Spearman rank correlation analysis showed that there was a positive correlation between TROP2 and p-Akt and vimentin (r = 0.313, P = 0.038; r = 0.402, P = 0.031) = 0.464, P = 0.026). CONCLUSION: The expression of TROP2 is associated with the malignant invasion and metastasis of papillary thyroid carcinoma and may serve as a potential target for the treatment of papillary thyroid carcinoma.