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目的：探讨细胞周期蛋白依赖性激酶ｃｄｋ２和ｃｄｋ４在前列腺增生（ＢＰＨ）和前列腺癌（ＰＣ）的发生发展过程中作用及其与ＰＣＮＡ之间关系。方法：应用免疫组化ＳＰ法检测１８例正常前列腺（ＮＰ）、６２例ＢＰＨ和３３例ＰＣ组织中ｃｄｋ２、ｃｄｋ４和ＰＣＮＡ的表达。结果：前列腺上皮和间质组织中均见ｃｄｋ２和ｃｄｋ４表达。ＮＰ中两者表达均分别显著低于ＢＰＨ和ＰＣ；ＢＰＨ的上皮细胞中两者表达均分别显著低于ＰＣ，但ＢＰＨ的间质细胞中两者表达与ＰＣ相比均无显著性差异。ＢＰＨ和ＰＣ中ｃｄｋ２及ｃｄｋ４表达与ＰＣＮＡ指数均呈正相关。结论：ｃｄｋ２和ｃｄｋ４异常表达参与ＢＰＨ和ＰＣ的发生发展过程，其可能是通过改变细胞周期及促进细胞异常增殖而起作用的。
AIM: To investigate the role of cdk2 and cdk4 in the development and progression of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and their relationship with PCNA. Methods: The expressions of cdk2, cdk4 and PCNA in 18 cases of normal prostate (NP), 62 cases of BPH and 33 cases of PC tissues were detected by immunohistochemical SP method. Results: Both cdk2 and cdk4 were expressed in epithelial and interstitial tissues of prostate. NP were significantly lower than that of BPH and PC respectively. The expression of both in epithelial cells of BPH was significantly lower than that of PC, but there was no significant difference between PCH and BPH. The expressions of cdk2 and cdk4 in PCH and PCH were positively correlated with PCNA index. Conclusion: The aberrant expressions of cdk2 and cdk4 are involved in the development and progression of BPH and PC, which may play a role in altering the cell cycle and promoting abnormal cell proliferation.