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[目的]观察2型糖尿病患者血清IL-18水平的变化,并探讨其临床意义。[方法]临床选择研究2型糖尿病病人67例,分为单纯糖尿病组(DM组,n=37例)和糖尿病肾病组(DN组,n=30例),并以正常健康人30例为正常对照组。所有研究对象均测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、24h尿微量白蛋白定量(24h-UA)和血清IL-18水平。[结果]DM组和DN组患者的的FPG、HbA1c和IL-18水平均较正常对照组明显升高(P﹤0.05);DM组和DN组对比,FPG、HbA1c无明显差异,但是DN组患者的24h-UA和IL-18水平明显高于DM组(P﹤0.05)。糖尿病肾病患者的IL-18水平与24h-UA有良好的正相关性(r=0.354,P﹤0.05)。[结论]IL-18参与了2型糖尿病肾病患者的发病过程,可以作为糖尿病肾病诊断和肾脏损害程度的临床实验室观察指标。
[Objective] To observe the change of serum IL-18 in patients with type 2 diabetes mellitus and to explore its clinical significance. [Methods] Sixty-seven patients with type 2 diabetes mellitus were selected clinically. The patients were divided into simple diabetic group (n = 37) and diabetic nephropathy group (n = 30) Control group. Fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), 24h urinary albumin (24h-UA) and serum IL-18 levels were measured in all the subjects. [Results] The levels of FPG, HbA1c and IL-18 in DM group and DN group were significantly higher than those in normal control group (P <0.05). There were no significant differences in FPG and HbA1c between DM group and DN group. However, DN group Patients 24h-UA and IL-18 levels were significantly higher than the DM group (P <0.05). The level of IL-18 in patients with diabetic nephropathy had a good positive correlation with 24h-UA (r = 0.354, P <0.05). [Conclusion] IL-18 is involved in the pathogenesis of type 2 diabetic nephropathy and can be used as a clinical laboratory index for the diagnosis of diabetic nephropathy and the degree of renal damage.