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目的 :探讨肿瘤转移抑制基因KAI1与乳腺癌转移的相关性。方法 :运用原位杂交法观察KAI1mRNA在转移性和非转移性乳腺癌组织中的表达。结果 :在无淋巴结转移的 12例乳腺癌病例中KAI1mRNA阳性表达为 9例 ,有淋巴结转移的 8例中阳性表达 1例。前者阳性率显著高于后者 (P <0 0 5 )。结论 :KAI1基因的低表达或不表达可能是某些高转移潜能乳腺癌的特征。
Objective: To investigate the relationship between tumor metastasis suppressor gene KAI1 and breast cancer metastasis. Methods: The expression of KAI1 mRNA in metastatic and non-metastatic breast cancer tissues was observed by in situ hybridization. Results: The positive expression of KAI1 mRNA in 12 cases of breast cancer without lymph node metastasis was 9 cases, and 1 case was positive in 8 cases with lymph node metastasis. The former positive rate was significantly higher than the latter (P <0 05). Conclusion: The low expression or non-expression of KAI1 gene may be a feature of some high metastatic potential breast cancers.