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目的探讨无创正压通气治疗COPD合并Ⅱ型呼吸衰竭的疗效。方法选取2010年6月-2011年10月收治的COPD合并Ⅱ型呼吸衰竭患者64例作为研究对象,将上述患者随机分为两组,观察组32例,在常规治疗的基础上给予无创正压通气治疗,对照组32例,仅给予常规治疗。比较两组患者的疗效。结果 (1)治疗后,所有患者的pH、动脉血氧分压(PaO2)显著升高,动脉二氧化碳分压(PaCO2)显著下降,治疗前后相比差异有统计学意义(P<0.05);观察组的pH、PaO2升高幅度显著大于对照组,PaCO2降低幅度显著大于对照组,两组比较差异有统计学意义(P<0.05)。(2)治疗后,所有患者的呼吸频率(RR)、心率(HR)显著降低,治疗前后相比差异有统计学意义(P<0.05);观察组的RR、HR降低幅度显著大于对照组,两组比较差异有统计学意义(P<0.05)。结论无创正压通气治疗COPD合并Ⅱ型呼吸衰竭疗效确切,该治疗技术可以在临床上推广与应用。
Objective To investigate the curative effect of noninvasive positive pressure ventilation on COPD with type Ⅱ respiratory failure. Methods Sixty-four patients with COPD and type Ⅱ respiratory failure who were admitted to our hospital from June 2010 to October 2011 were selected as the study subjects. The above patients were randomly divided into two groups. The observation group received 32 cases of non-invasive positive pressure Ventilation treatment, control group of 32 patients, only given conventional treatment. Compare the efficacy of two groups of patients. Results (1) After treatment, the PaO2 and PaCO2 of all the patients were significantly increased (P <0.05); the PaO2 and PaCO2 of all the patients were significantly decreased (P <0.05) The increase of pH and PaO2 in the group was significantly larger than that in the control group, and the decrease of PaCO2 in the group was significantly larger than that in the control group. There was significant difference between the two groups (P <0.05). (2) Respiratory rate (RR) and heart rate (HR) of all patients after treatment were significantly lower than those before treatment (P <0.05). The RR and HR of the observation group were significantly lower than those of the control group The difference between the two groups was statistically significant (P <0.05). Conclusion Noninvasive positive pressure ventilation is effective in treating COPD with type Ⅱ respiratory failure. The treatment technique can be widely applied in clinic.