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目的观察根除Ｈｐ对老年人十二指肠溃疡再出血的影响。方法选择７０例Ｈｐ感染十二指肠溃疡并出血的老年病人并随机分成Ａ、Ｂ２组。Ａ组应用奥美拉唑（洛赛克）、胶态次枸橼酸铋（德诺）胶囊和羟氨苄青霉素进行根除Ｈｐ治疗；Ｂ组单独用洛赛克治疗。４周后停药追踪观察１８个月。结果２组溃疡愈合率分别为１００％、９６．１％，２者比较无显著性差异（Ｐ＞０．０５）；Ａ、Ｂ２组Ｈｐ根除率分别为８５％和１６．６％，２者比较有显著性差异（Ｐ＜０．０５）。随访１８个月后，Ａ、Ｂ２组再出血率分别为２．９４％和２８％，２者比较有显著性差异（Ｐ＜０．０５）。结论根除Ｈｐ对老年人十二指肠溃疡再出血有一定的预防作用。
Objective To observe the effect of eradication of Hp on rebleeding of duodenal ulcer in the elderly. Methods Seventy elderly patients with Hp infection of duodenal ulcer and bleeding were randomly divided into A and B2 groups. In group A, omeprazole (Losec), colloidal bismuth subhum citrate (dex) capsules and amoxicillin were used to eradicate Hp; group B was treated with Losec alone. Four weeks later, drug withdrawal was observed for 18 months. Results The healing rates of ulcer in the two groups were 100% and 96.1%, respectively. There was no significant difference between the two groups (P> 0.05). The eradication rates of Hp in group A and B2 were 85% and 16.6% There was significant difference (P <0.05). After 18 months of follow-up, the rates of rebleeding in group A and group B2 were 2.94% and 28%, respectively. There was a significant difference between the two groups (P <0.05). Conclusion Eradication of Hp may play a preventive role in re-bleeding of duodenal ulcer in the elderly.