目的将明胶与壳聚糖用作微胶囊的壁材,制备西咪替丁缓释微囊。方法以明胶用量(A)、壳聚糖用量(B)、戊二醛用量(C)等三因素三水平进行L9(34)正交实验,从累积释放度方面考察,优选最佳工艺配方。结果对微囊释放度影响作用较大的因素顺序是B>A>C,选出最佳处方工艺为A2B3C1。结论以明胶与壳聚糖制备的含西咪替丁药物微囊具有良好的缓释作用。 Objective To use gelatin and chitosan as microcapsule wall materials to prepare cimetidine sustained-release microcapsules. Methods The orthogonal experiment of L9 (34) with three factors and three levels of gelatin (A), chitosan dosage (B) and glutaraldehyde dosage (C) was used to optimize the formula. Results The order of the factors that had a significant effect on the release of microcapsules was B> A> C, and the optimal prescription was A2B3C1. Conclusion The microcapsules containing cimetidine prepared by gelatin and chitosan have a good sustained-release effect.