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目的 :研究经直肠前列腺穿刺活检 (TPB)对血清前列腺特异抗原 (PSA)值的影响。 方法 :2 0例因PSA值升高和 (或 )经直肠指检 (DRE)前列腺异常的病人 ,行TPB术 ,分别于术前及术后 0 .5h、1周、1个月检测血清PSA值。 结果 :术前及术后 0 .5h、1周、1个月血清PSA值分别为 (12 .2 3± 8.6 2 )、(34.90± 4 1.5 3)、(2 3.5 9± 2 0 .78)、(11.31± 6 .95 ) μg L。术后 0 .5h血清PSA值均较术前明显升高 (P <0 .0 5 ) ,其后逐渐下降 ,1周时有 17例 (85 % )PSA值仍明显高于术前 (P <0 .0 5 ) ,至术后 1个月时血清PSA值才降至基线水平 ,与术前比较差异无显著性 (P >0 .0 5 )。 结论 :TPB可致血清PSA值明显升高 ,随时间推移血清PSA值逐渐下降 ,术后 1个月才恢复到一个稳定的基线水平
Objective: To investigate the effect of transrectal prostate biopsy (TPB) on the value of serum prostate specific antigen (PSA). Methods: Twenty patients with prostatic abnormality due to PSA and / or DRE were treated with TPB and the serum PSA was measured before and at 0.5h, 1 week and 1 month value. Results: The serum PSA levels at 0, 5, 1, and 1 month before operation and after operation were (12.23 ± 8.62), (34.90 ± 4.15), (23.59 ± 2.78) , (11.31 ± 6.95) μg L. The serum PSA levels at 0 and 5 hours after operation were significantly higher than those before operation (P <0.05), and then decreased gradually. At 1 week, the PSA values of 17 patients (85%) were still significantly higher than those before operation (P < 0.05). Serum PSA was only reduced to baseline level at 1 month after operation, showing no significant difference compared with that before operation (P> 0.05). CONCLUSION: The serum PSA level of TPB can be significantly increased. The serum PSA level gradually decreases over time and returns to a stable baseline one month after operation