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目的:通过检测动态血压、内皮细胞合成和分泌的血管活性物质及心脏结构,探讨老年高血压患者血压晨峰与内皮功能、心脏重构的关系。方法:将60例老年高血压患者按血压晨峰程度是否>50 mm Hg分为2组,A组血压晨峰≥50 mm Hg(33例),B组血压晨峰<50 mm Hg(27例)。所有受试者采用硝酸还原酶法,放射免疫法分别测定血清一氧化氮、内皮素含量,并进行超声心动图检查。结果:A组血清一氧化氮含量较B组低(P<0.05),血清内皮素含量较B组高(P<0.05);左心室肥厚发生率,左心房内径增大发生率较B组高(P<0.05)。结论:老年高血压患者血压晨峰程度与内皮功能损伤程度、心脏重构密切相关。
OBJECTIVE: To investigate the relationship between peak morning blood pressure, endothelial function and cardiac remodeling in elderly hypertensive patients by detecting ambulatory blood pressure, the synthesis and secretion of vasoactive substances and cardiac structure in endothelial cells. Methods: Sixty elderly hypertensive patients were divided into two groups according to the peak morning blood pressure> 50 mm Hg. The peak pressure of morning blood pressure in group A was ≥50 mm Hg (n = 33), and the peak pressure of morning blood pressure in group B was less than 50 mm Hg (n = 27) ). All subjects using nitric acid reductase method, radioimmunoassay were measured serum nitric oxide, endothelin levels, and echocardiography. Results: The serum nitric oxide level in group A was lower than that in group B (P <0.05), and the content of serum endothelin was higher in group A than in group B (P <0.05). The incidence of left ventricular hypertrophy and left ventricular hypertrophy in group A were higher than those in group B (P <0.05). Conclusion: The peak of morning blood pressure in elderly hypertensive patients is closely related to the degree of endothelial dysfunction and cardiac remodeling.