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用临床细胞免疫学检测方法，对损毁大脑前额叶背外侧部皮层手术前、手术后７天和手术后３０天的猕猴外周血液淋巴细胞的４种免疫花环（Ｅｔ、Ｅａ、ＺＹＣ和ＭＥ花环）进行了跟踪监测，并与假手术组进行对照。结果表明：损毁大脑前额叶皮层后，其外周血活化Ｔ淋巴细胞花环率（Ｅａ）和Ｂ淋巴细胞的小鼠红细胞花环率（ＭＥ）均在手术后７天显著下降；直到手术后３０天仍显著低于手术前。而总Ｔ淋巴细胞花环率（Ｅｔ）和酵母多糖补体复合物花环率（ＺＹＣ）则在手术后７天显著下降，在手术后３０天又回复。这些结果提示：大脑前额叶皮层对机体免疫机能具有一定的调节联系作用，损毁大脑前额叶皮层后，可引起机体淋巴细胞免疫功能下降，其作用机理尚待进一步研究
Four kinds of immunocysts (Et, Ea, ZYC and ME rosette) of peripheral blood lymphocytes of macaque before operation, 7 days after operation and 30 days after operation were destroyed by clinical cell immunology assay. Follow-up monitoring was performed and compared with sham operation group. The results showed that both the Ea of activated T lymphocytes and the ME of erythrocytes of B lymphocytes in the prefrontal cortex of the injured rats decreased significantly 7 days after the operation; Significantly lower than before surgery. However, total T lymphocyte rosette rate (Et) and zymosan complement complex rate (ZYC) decreased significantly 7 days after surgery and recovered 30 days after surgery. These results suggest that the prefrontal cortex of the brain has a regulatory role in the immune function of the body, and the damage to the prefrontal cortex of the brain can cause the decline of the immune function of the body’s lymphocytes. The mechanism of action is yet to be further studied