目的：探讨脂肪组织源性肿瘤与ｃｍｙｃ 和ｐ５３ 基因的关系。方法：采用 Ｌ Ｓ Ａ Ｂ 免疫组化法，检测６２ 例脂肪组织源性肿瘤及瘤样病变ｃｍｙｃ 和ｐ５３ 蛋白表达。结果：ｃｍｙｃ 在正常脂肪组织、脂肪组织良性病变中几乎不表达，主要在脂肪肉瘤中表达。ｐ５３ 只在脂肪肉瘤中表达。分化较高类型脂肪肉瘤ｃｍｙｃ 和ｐ５３ 表达阳性率明显低于分化较低类型脂肪肉瘤。脂肪肉瘤中，ｃｍｙｃ 和ｐ５３ 表达呈正相关。结论：实验结果提示，ｃｍｙｃ 、ｐ５３ 蛋白与脂肪肉瘤的发生、细胞分化和恶性程度有关。它们可作为判断脂肪肉瘤分化程度及恶性程度的参考指标。在脂肪肉瘤的发生发展中两者可能起协同作用。 Objective: To investigate the relationship between adipose tissue-derived tumors and cmyc and p53 genes. Methods: The expression of cmyc and p53 protein in 62 adipose tissue-derived tumors and tumor-like lesions was detected by L S A B immunohistochemistry. RESULTS: C-myc was hardly expressed in benign lesions of normal adipose tissue and adipose tissue and was mainly expressed in liposarcoma. P53 is only expressed in liposarcoma. The positive rates of c-myc and p53 expression in the higher-differentiation type liposarcoma were significantly lower than those in the lower-type liposarcoma. In liposarcoma, there is a positive correlation between cmyc and p53 expression. Conclusion: The experimental results suggest that the cmyc and p53 proteins are related to the occurrence of liposarcoma, cell differentiation and malignancy. They can serve as a reference for judging the degree of differentiation and malignancy of liposarcoma. Both may play a synergistic role in the development of liposarcoma.