【摘 要】
：
To investigate the effect of the anti-endotoxic part of Radix lsatidis on the expression of moesin mRNA in murine tissues induced by lipopolysaccharide (LPS), t
【机 构】
：
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
【出 处】
：
华中科技大学学报（医学）（英德文版）
【基金项目】
：
卫生部资助项目;国家自然科学基金
论文部分内容阅读
To investigate the effect of the anti-endotoxic part of Radix lsatidis on the expression of moesin mRNA in murine tissues induced by lipopolysaccharide (LPS), the sample solution of F022 part from Radix lsatidis was intraperitoneally administered to experimental mice, and the lipopolysaccharide (LPS) were injected into the tail vein, and then the tissues of liver, kidney and spleen were colleted and cut into slices. The mRNA was detected by moesin mRNA hybridization in situ. The staining results were observed under microscope. It was found that moesin mRNA expression was increased in the tissues of liver, kidndy and spleen in mice treated with LPS, while in the mice pre-treated with F022 part from Radix Isatidis, the LPS-induced moesin mRNA expressions in these tissues were inhibited in a dose-dependant manner. Our study showed that F022 part from Radix Isatidis can inhibit the LPS-induced expression of moesin mRNA in the tissues of liver, kidney and spleen in mice.
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