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1972年Joker 描述了一种原发性皮肤肿瘤,命名为“管状癌”。随后,许多作者用光镜、电镜和免疫组化方法对此瘤进行深入研究,提出了Merkel 细胞瘤(推测该肿瘤来自表皮和真皮的Merkel 氏神经触觉细胞)、皮肤原发性神经内分泌癌等诊断名称。本文作者报道了纪念医院13例皮肤神经内分泌癌的临床病理特征。全部病例均经电镜观察。对其中8例典型的Merkel 细胞瘤的石蜡切片作免疫组化测定(改良的PAP 法),即用兔抗血清(Dako)直接抗5—羟色胺、降钙素和肾上腺皮质激素。分阳性对照组(切片中有上述反应物但无内分泌肿瘤)和阴性对
In 1972 Joker described a primary skin tumor, named “tubular cancer.” Subsequently, many authors used light microscopy, electron microscopy, and immunohistochemistry to perform in-depth studies on this tumor, presenting Merkel’s cell tumors (presumably Merkel’s neurotact cells from the epidermis and dermis), and primary neuroendocrine cancers of the skin. Diagnostic name. The author of this article reported on the clinicopathological features of 13 cases of cutaneous neuroendocrine carcinoma in Memorial Hospital. All cases were observed by electron microscopy. Paraffin sections of 8 cases of typical Merkel cell tumors were immunohistochemically assayed (modified PAP method) using rabbit antiserum (Dako) directly against serotonin, calcitonin, and corticosteroids. The positive control group (with the above reaction but no endocrine tumor in the section) and the negative pair