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目的调查慢性乙型肝炎病毒感染者幽门螺杆菌感染情况,分析患者感染幽门螺杆菌与其并发症发生发展的关系。方法分别采用ELISA法和PCR法测定乙型肝炎病毒血清学标志物及其病毒DNA,采用流行病学调查方法探究幽门螺杆菌感染情况。结果 334例慢性乙型肝炎患者幽门螺杆菌感染阳性者226例,感染率为67.66%。226例幽门螺杆阳性患者血清丙氨酸氨基转氨酶(ALT)和总胆红素(TBil)分别为(150±89)U/L和(38±28)(μmol/L),108例幽门螺杆阴性患者ALT和TBil分别为(82±26)U/L和(27±23)(μmol/L),幽门螺杆感染阳性患者ALT高于幽门螺杆感染阴性患者,差异有统计学意义(χ2=7.0657,P<0.05)。且感染幽门螺杆菌的慢性乙型肝炎患者HBV复制率要高于未感染患者。慢性乙型肝炎病毒感染者并发肝性脑病、血氨增高、自发性腹膜炎、消化道出血时,患者幽门螺杆菌感染的阳性率分别为82.98%、68.11%、70.97%和69.05%。结论慢性乙型肝炎病毒感染者幽门螺杆菌感染率较高,患者感染幽门螺杆菌与其并发症的发生发展相关。
Objective To investigate the prevalence of Helicobacter pylori infection in patients with chronic hepatitis B infection and to analyze the relationship between Helicobacter pylori infection and its complications. Methods Serological markers of hepatitis B virus and its DNA were determined by ELISA and PCR respectively. The prevalence of Helicobacter pylori infection was investigated by epidemiological investigation. Results Among the 334 patients with chronic hepatitis B, 226 were positive for Helicobacter pylori infection, the infection rate was 67.66%. The serum alanine aminotransferase (ALT) and total bilirubin (TBil) in 226 pyloric screw positive patients were (150 ± 89) U / L and (38 ± 28) μmol / L, respectively. ALT and TBil were (82 ± 26) U / L and (27 ± 23) μmol / L, respectively. The ALT in patients with positive pyloric screw infection was higher than that in patients with negative pyloric screw infection, the difference was statistically significant (χ2 = 7.0657, P <0.05). HBV infection rate in chronic hepatitis B patients infected with H. pylori is higher than that in non-infected patients. The positive rates of Helicobacter pylori infection were 82.98%, 68.11%, 70.97% and 69.05% respectively in patients with chronic hepatitis B virus complicated with hepatic encephalopathy, elevated serum ammonia, spontaneous peritonitis and gastrointestinal bleeding. Conclusion The infection rate of Helicobacter pylori in chronic hepatitis B virus infection is high, and the infection of Helicobacter pylori in patients is related to the occurrence and development of its complications.