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目的探讨下丘脑错构瘤致儿童性早熟的临床特征及治疗方法。方法对我院自2003年3月至2010年5月收治的12例下丘脑错构瘤患儿的临床资料进行回顾性分析,总结临床特征及治疗方法。结果 10例非保守治疗患儿治疗均成功,其中全部切除7例,大部切除3例;术后出现动眼神经麻痹1例,电解质紊乱1例,经对症治疗后好转。2例γ-刀治疗患儿1例症状得到控制,1例患儿无效转手术切除。对12例患儿行为期1～4年的随访观察,9例手术患儿痊愈6例,好转3例,保守治疗2例患儿症状得到控制。结论下丘脑错构瘤致儿童性早熟采用手术治疗效果较为理想,是优先考虑的治疗方法。
Objective To investigate the clinical features and treatment of precocious puberty in children with hypothalamic hamartoma. Methods The clinical data of 12 children with hypothalamic hamartoma treated in our hospital from March 2003 to May 2010 were analyzed retrospectively to summarize the clinical features and treatment methods. Results 10 cases of non-conservative treatment of children were successful, including all resected in 7 cases, most of the resection in 3 cases; postoperative oculomotor nerve paralysis in 1 case, electrolyte imbalance in 1 case, after symptomatic treatment improved. Two cases of γ-knife treatment of children with symptoms in 1 case was controlled, 1 case of children with no effective surgical resection. Follow-up observation of 12 children with behavioral period of 1 to 4 years showed that 6 of 9 cases recovered, 3 cases improved, and 2 cases of conservative treatment were controlled. Conclusion Hypothalamic hamartoma caused by precocious puberty in children with surgical treatment is more ideal, is the preferred treatment.